Abstract #4693

Inter-individual variability in rapid eye movement sleep is associated with brain white matter structure

Shuqin Zhou¹, Qihong Zou², Jing Xu², Jiahui Deng³, Zihui Su², Tianyi Qian⁴, Thomas Beck⁵, Changwei Wu⁶, Hongqiang Sun³, and Jia-Hong Gao²

¹Department of Biomedical Engineering, Peking University, Beijing, People's Republic of China, ²Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, People's Republic of China, ³Sixth Hospital, Peking University, Beijing, People's Republic of China, ⁴MR Collaborations NE Asia, Siemens Healthcare, Beijing, People's Republic of China, ⁵Application Development, Siemens Healthcare, Erlangen, Germany, ⁶Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan

Previous animal studies indicated that sleep is important for cell membrane and myelin maintenance in the brain. Research further suggests that variability in sleep structure may be associated with brain white matter microstructure. In this study, we investigate the relationship between sleep structure parameters evaluated with polysomnography and brain white matter characteristics, as measured by MR diffusion tensor imaging. We find that inter-subject variability of regional white matter characteristics may explain the differences in sleep structure across participants.

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