The IIT Human Brain Atlas contains anatomical, DTI, HARDI templates, probabilistic gray matter (GM) labels, probabilistic connectivity-based white matter labels, and major fiber-bundles of the young adult brain. During development of the atlas, spatial normalization was accomplished based on diffusion data. Consequently, matching of the anatomical information of T1-weighted images was not maximized, blurring the T1-weighted template and tissue probability maps, increasing the noise of the T1-weighted template, and lowering confidence of GM labeling and GM label precision. The present work enhanced the quality of the T1-weighted template, tissue probability maps, and GM labels of the IIT Human Brain Atlas.
