Abstract #4676

Free Water Estimation Improves in vivo Diffusion MRI Remote from the Lesion Site in Rat Spinal Cord Injury

Matthew Budde¹, Nathan Skinner², Brian Schmit³, and Shekar Kurpad¹

¹Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ²Medical College of Wisconsin, Milwaukee, WI, United States, ³Biomedical Engineering, Marquette University, Milwaukee, WI, United States

Diffusion tensor imaging (DTI) of the spinal cord remote from the site of injury has been shown to be a surrogate marker of spinal cord injury (SCI) severity. In this work, detection of injury severity with in vivo diffusion MRI of the rat cervical cord following a thoracic SCI was improved with advanced diffusion MRI signal modelling compared to DTI.

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