We measured the profile of major metabolites longitudinally using MRS in spinal cord gray matter of kainic acid (KA) injured rats at both 7 and 14 days post KA administration and correlated their concentrations with functional outcomes assessed by the Basso, Bresnahan, and Beattie (BBB) Open Field Locomotor scores. Our preliminary findings indicate that metabolite concentrations in the lower lumbar spinal cord gray matter, caudal to the injury epicenter, as detected by in vivo 1H-MRS, could be used as injury and recovery biomarkers in SCI animal models.
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