Abstract #4647

31P MR Spectroscopic Imaging of the Human Brain at 7T

Jimin Ren¹, Ty Shang², A. Dean Sherry^1,3, and Craig R. Malloy^1,4

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Chemistry, Unversity of Texas at Dallas, Richardson, TX, ⁴VA North Texas Health Care System, Dallas, TX, United States

³¹P MRS is capable of probing cerebral metabolism in vivo, but clinical applications are limited by poor spatial resolution. This study demonstrates that ³¹P MRS imaging (MRSI) at 7T can offer high quality spectral data that enables cross-sectional mapping of various phosphorus-bearing metabolites in normal human brain. In a patient with prior ischemic stroke, high-energy phosphates were depleted and extracellular inorganic phosphate was increased in the stroke lesion.

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