Abstract #4630

Feasibility of 1H-MRS brain temperature map to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease

Takamasa Namba¹, Kuniaki Ogasawara¹, Hideaki Nishimoto¹, Daiya Ishigaki¹, Yoshichika Yoshioka^2,3, Toshiyuki Murakami¹, Makoto Sasaki⁴, Masakazu Kobayashi¹, Kenji Yoshida¹, Ikuko Uwano⁴, Shunrou Fujiwara¹, Kazunori Terasaki⁵, and Akira Ogawa¹

¹Department of Neurosurgery, School of Medicine, Iwate Medical University, Morioka, Japan, ²Center for Information and Neural Networks (CiNet), NICT and Osaka University, Suita, Japan, ³Biofunctional Imaging, Immunology Frontier Reseach Center, Osaka University, Suita, Japan, ⁴Division of Ultra-High Field MRI, School of Medicine,Iwate Medical University, Morioka, Japan, ⁵Cyclotoron Reseach Center, School of Medicine, Iwate Medical University

Deep cerebral white matter (CWM) like the centrum semiovale is vulnerable to ischemic injury. Brain temperature (BT) was associated with cerebral hemodynamic abnormalities in patients with chronic ischemia. We investigated whether the BT distribution map by multi-voxel¹H-MRS were associated with the cerebral hemodynamic abnormalities assessed by positron emission tomography (PET) in the CWM region of patients with unilateral chronic major cerebral artery steno-occlusive disease. The BT map quantitatively and qualitatively correlated with PET images, especially oxygen extraction fraction. This may help to identify the patients at high risk for the stroke recurrence.

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