In the current study, we used a graph theory-based network measurements named degree centrality (DC) to identify main cortical hubs in the brain network architecture at voxel level affected in ADHD. Then, functional connectivity maps were generated with seeded at altered DC to detect the brain changes at large-scale level. Finally, we found the disconnection within cortico-thalamus and cortico-striatal loops in ADHD patients, which may associated with inattention and cognitive function deficits.
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