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Abstract #4590

Vascular-metabolic and GABAergic inhibitory modulation of neural variability. A combined fMRI and PET study

Pengmin Qin1,2, Niall W Duncan2, David Yen-Ting Chen3, Zirui Huang4, Chien-Yuan Eddy Lin5,6, Christine Wiebking7, Chien-Mu Lin8, Che-Ming Yang8, Ying-Chi Tseng3, Georg Northoff9, and Timothy Lane2

1Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People's Republic of China, 2Brain and Consciousness Research Centre, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan, 3Department of Radiology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, 4Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Ottawa, Canada, 5GE Healthcare, Taipei, Taiwan, 6GE Healthcare MR Research China, Beijing, People's Republic of China, 7Applied Emotion and Motivation Research, Institute for Psychology and Education, Universität Ulm, Ulm, Germany, 8Department of Nuclear Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, 9Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa, Ottawa, Canada

We sought to investigate the mechanism involved in temporal variability (TV) changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC). The aim of this study was to use the change between the EC and EO states to identify the potential mechanisms involved in TV modulation.

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