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Abstract #4577

The Sensorimotor Network Dysfunction in Migraineurs WithoutAura: A Resting-state fMRI study

Jilei Zhang1, Jingjing Su2, Mengxing Wang1, Qian Yao2, Haifeng Lu1, Hui Zhang1, Jianqi Li1, Jian-Ren Liu2, and Xiaoxia Du*1

1Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, People's Republic of China, 2Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

In current study, we analyzed resting-state fMRI data for the first time to evaluate the dysfunction of the sensorimotor network in migraineurs without aura by applying regional homogeneity (ReHo), amplitudes of low-frequency fluctuation (ALFF) and degree centrality (DC) analysis methods. The ReHo, DC and ALFF values were decreased in the S1 and PMC indicating the sensorimotor network dysfunction in migraineurs without aura. These changes may result in disruption of discrimination of sensory features of pain, thereby affecting nociception pathways. Non-invasive brain stimulation could be applied to sensorimotor network to modulate headache pain in future therapies.

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