Abstract #4573

Cerebral perfusion and reactivity in Impaired Glucose Tolerance and Type-2 Diabetes using arterial spin labeling

Maria-Eleni Dounavi^1,2, Aneurin J. Kennerley^2,3, Solomon Tesfaye⁴, Christopher Martin^2,3, Dinesh Selvarajah⁴, Elaine Boland¹, and Iain D. Wilkinson^1,2

¹Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, ²Neuroimaging in Cardiovascular Disease (NICAD) Network, University of Sheffield, Sheffield, United Kingdom, ³Department of Psychology, University of Sheffield, Sheffield, United Kingdom, ⁴Academic Unit of Diabetes, University of Sheffield, Sheffield, United Kingdom

This study evaluates cerebral perfusion and cerebrovascular reserve (CVR) in impaired glucose tolerance and patients with type-2 diabetes using QUASAR Arterial Spin Labeling. CVR was evaluated as the change in gray matter CBF in response to a pharmacological stimulus. The developed processing pipeline was based on published QUASAR theory, modified to account for excessive motion and partial volume effects. Results show that baseline CBF is within the expected range. In patients with T2DM and IGT there is a significantly lower value of Cerebrovascular Reserve compared to healthy, normoglycaemic individuals.

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