Abstract #4555

Ex-vivo Quantitative Susceptibility Mapping of Human Brain Hemispheres

Arnold M. Evia¹, Aikaterini Kotrotsou¹, Robert J. Dawe^1,2,3, Sue E. Leurgans^2,4, Julie A. Schneider^2,4,5, David A. Bennett^2,4, and Konstantinos Arfanakis^1,2,3

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States, ⁴Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁵Department of Pathology, Rush University Medical Center, Chicago, IL, United States

In order to establish the role of quantitative susceptibility mapping (QSM) as a diagnostic tool in aging, it is essential to combine QSM with direct assessments of age-related brain pathologies on the same individuals. Using ex-vivo QSM for this purpose may be more advantageous than in-vivo QSM, since ex-vivo QSM assesses the brain in the same condition as histology, and allows imaging of older adults independent of frailty level. However, being able to translate ex-vivo QSM findings to in-vivo is crucial. Therefore, our goal was to investigate the effects of death and fixation on brain QSM data collected ex-vivo.

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