The ihMT (inhomogeneous Magnetization transfer) signal qualitatively demonstrates sensitivity for myelinated structures. However, image intensity and contrast vary with the saturation parameters, further questioning the specificity of ihM for myelin. This study validated ihMT as a myelin biomarker by demonstrating for various ihMT sequences, linear relationships between ihMT signal and intensity of fluorescence microscopy (a quantitative myelin specific histology technique) collected in plp-GFP mouse brain.
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