Abstract #4541

Single-scan, whole-brain functional network mapping using optogenetic fMRI with CBV

Andrew J Weitz¹, ManKin Choy², Ben A Duffy², Jia Liu², and Jin Hyung Lee^1,2,3,4

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ³Neurosurgery, Stanford University, Stanford, CA, United States, ⁴Electrical Engineering, Stanford University, Stanford, CA, United States

Optogenetic fMRI studies have traditionally required significant scan averaging to achieve signal-to-noise ratios sufficient for whole-brain functional network mapping. As a result, more scan time is required, and measurements may not directly translate to accompanying behavioral paradigms that employ a single stimulation. Here, we used a SPION-based MRI contrast agent to enable single-scan functional network mapping with CBV during optogenetic stimulation of the thalamic submedial nucleus. Measurement of CBV led to significant activations detected at the site of stimulation and downstream mono- and polysynaptically connected regions. In comparison, single-scan BOLD measurements led to minimal detectable responses to stimulation.

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