This study investigates diffusion MRI changes after treatment with irreversible electroporation (IRE) in a murine cancer model. The mean and standard deviation of the ADC in regions of interest covering the whole tumors increased 1 day after treatment and then returned gradually to the pre-treatment values. A strong correlation was found between the volume increase and the maximum relative change in ADC mean and standard deviation. Therefore we propose diffusion MRI as an early tool to predict the outcome of IRE treatment in tumors.
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