Probing Tumor Oxygenation Response to Hypoxic Gas Breathing
Donghan Mo Yang1, Tatsuya J Arai1, James Campbell1, and Ralph P Mason1
1Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, United States
Tumor oxygenation response to hypoxic gas breathing is studied in rat 13762NF breast tumors using BOLD and TOLD MRI, with hyperoxic gas breathing as reference. Time course of R2* and R1-weighted signal is analyzed for 100%, 16%, and 14% O2 breathing challenges, respectively. Evidence for decreased blood oxygen saturation (sO2) and decreased tissue oxygen partial pressure (pO2) is observed, revealing different patterns depending on the tumor size.
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