Abstract #4494

On Molecular Aspects of Ktrans and Angiogenesis: Cerebral Gliomas

Charles S. Springer, Jr.¹, Xin Li¹, Seymur Gahramanov², Martin M. Pike¹, William D. Rooney¹, and Edward A. Neuwelt³

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Neurosurgery, University of New Mexico, Albuquerque, NM, United States, ³Blood Brain Barrier Program, Oregon Health & Science University, Portland, OR, United States

It is often thought that tumor K^trans value differences correspond to changes in capillary contrast agent (CA) permeability. We show this is not the case for implanted glioma in rat brain. Over an almost eight-fold K^trans change, the tumor CA extravasation rate constant k_pe remains relatively fixed, as if regulated, but at a value greater than normal. The K^trans changes reflect cerebral blood volume fraction changes.

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