The aim was to develop and validate a robust and accurate method of MR-IGRT delivery to abdominal targets in the mouse that takes advantage of the strengths of each of its components: MRI for soft tissue contrast and target identification, CBCT for accurate dose calculation and IGRT for accurate, collimated X-ray beam delivery. A multimodality cradle was developed and evaluated to enable transfer of the mouse between MR and the IGRT platform. Additionally, each step of the MG-IGRT process was validated, both in vitro using BANG gel dosimeters and in vivo by targeting the adrenal glands in mice.
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