Abstract #4480

Dietary Fat Results in Increased Tumor Burden in a Mouse Model of Human Triple-Negative Breast Cancer Based on Magnetic Resonance Imaging and Histology

Devkumar Mustafi¹, Sully Fernandez², Erica Markiewicz¹, Xiaobing Fan¹, Marta Zamora¹, Jeffrey Mueller³, Matthew J Brady², Suzanne D Conzen⁴, and Gregory S Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Medicine, Sections of Adults and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, United States, ³Pathology, The University of Chicago, Chicago, IL, United States, ⁴Medicine, the Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States

Breast cancer is the most commonly diagnosed malignancy among women in the United States and the second leading cause of cancer mortality worldwide. Epidemiological studies suggest an increase in the risk of triple-negative breast cancer (TNBC) in association with a high animal fat diet. Based on previous MRI studies in SV40Tag mice, we examined the effect of pre-pubertal exposure to high dietary fat in this model of TNBC. The results reported here demonstrate that a high animal fat diet significantly increased the number of aggressive cancers detected by MRI in a mouse model of human TNBC.

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