MRI using i.v. administered fluorine-19 loaded nanoparticles (NPs) allows the tracking of inflammatory cell migration. The inherently low SNR limits the precise localization of 19F-labeled inflammatory cells, because large voxel sizes are needed to collect sufficient signal. To overcome this, we show here the first use of a novel 19F cryogenic quadrature RF surface probe at ultrahigh field to substantially boost SNR beyond that of state-of-the-art room temperature RF coils, while facilitating the acquisition of better spatially-resolved images within shorter scan times.
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