In-vivo Detection of Acute Intracellular Acidification in Glioblastoma Multiforme by AACID CEST MRI Following a Single Dose of Cariporide and Quercetin
Mohammed Albatany1,2, Alex Li2, Susan Meakin3, and Robert Bartha1,2
1Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, 2The Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada, 3Department of Biochemistry, University of Western Ontario, London, ON, Canada
Identification of tumor boundaries is challenging due to the infiltrative nature of the cancer. Cariporide and quercetin are drugs approved for human use that target different pH regulatory mechanisms in cancer. The goal of the current study is to determine whether chemical exchange saturation transfer (CEST) MRI is sensitive to tumor acidification after cariporide or quercetin injection. In mice with U87 glioblastoma brain tumors, we found both drugs significantly reduced tumor pH within two hours of treatment measured by CEST MRI. The physiological change induced by cariporide or quercetin could help localize brain cancer and monitor tumor response to chemotherapy. This unique approach to cancer detection does not require injection of an imaging contrast agent.
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