Abstract #4360

Value of Tumor Stiffness Measured with MR Elastography for Assessment of Response of Hepatocellular Carcinoma to Locoregional Therapy

Sonja Gordic^1,2, Jad Bou Ayache³, Paul Kennedy ¹, Cecilia Besa¹, Mathilde Wagner¹, Octavia Bane¹, Richard Ehman⁴, Edward Kim³, and Bachir Taouli^1,3

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Radiology, Mayo Clinic, Rochester, MN, United States

We correlated tumor stiffness (TS) measured with MR elastography (MRE) to degree of tumor enhancement and necrosis on contrast-enhanced T1-weighted imaging (CE-T1WI) in hepatocellular carcinomas (HCC) treated with locoregional therapy. Patients with HCC who underwent locoregional treatment and controls with newly diagnosed untreated HCC were included. TS values were obtained by placing regions of interest (ROIs) over HCCs on stiffness maps. Visual assessment of tumor necrosis on subtraction images and calculation of enhancement ratios by placing ROIs over tumors on CE-T1WI was performed. TS measured with MRE showed a significant correlation with tumor enhancement and necrosis.

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