Abstract #4358

HCC treated with 90Yttrium radioembolization: can pre-treatment and 6week post-treatment volumetric ADC histogram measurements predict subsequent tumor response?

Sonja Gordic^1,2, Mathilde Wagner^1,3, Riccardo Zanato¹, Stefanie Hectors¹, Cecilia Besa¹, Edward Kim⁴, and Bachir Taouli^1,4

¹Translational and Molecular Imaging Institute, New York, NY, United States, ²Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ³Radiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, ⁴Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, Switzerland

We evaluated the potential of volumetric ADC histogram measurements (vADC) obtained pre- and 6 weeks (6w) post-treatment for prediction of HCC response to ⁹⁰Yttrium radioembolization (RE). 22 patients underwent MRI at baseline and 6w after RE using a routine liver MRI protocol including DWI. Tumor response was assessed by mRECIST at 6 months post treatment. vADC mean, median and mode obtained at 6w post-treatment were significantly different between patients with partial/complete response vs. those with stable/progressive disease, and were a significant predictor of complete tumor response at 6 months, with vADC mode performing best. Pre-treatment vADC did not have any predictive value for response.

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