Abstract #4262

The Effects of Long-Term Physical Intervention for Active Ageing on the White Matter Hyperintensities in Older Adults

Toshiharu Nakai^1,2, Noriko Ogama³, Takashi Sakurai⁴, Mika Ueno¹, Sachiko Kiyama^1,5, and Ayuko Tanaka^1,6

¹NeuroImaging & Informatics, National Center for Geriatrics & Gerontology, Ohbu, Japan, ²Department of Radiological Science, Nagoya University Graduate School of Medicine, Nagoya, Japan, ³Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Ohbu, Japan, ⁴Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics & Gerontology, Ohbu, Japan, ⁵College of Liberal Arts and Sciences, Mie University, Tsu, Japan, ⁶Faculty of Human Sciences, Kobe Shoin Women's University, Kobe, Japan

The relationship between the history of participation in community based physical exercise activity and the volume of white matter hyperintensity was evaluated in order to investigate the long-term effects of physical exercises on the neurophysiological status of brain to support cognitive processing in older adults. The FLAIR MR images obtained from 54 community dwelling older adults were segmented semi-automatically and the WMH volumes were quantified. It was suggested that long-term physical exercises more than 5 years for 90 minutes once per week may potentially reduce the progress of WMH lesions as well as the risk of fall.

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