Medulloblastoma in adults is very rare and shows prognostically relevant histological and genetic subtypes. Within a nation-wide multicenter study, pre-surgical MRIs of 28 cases were analysed to identify imaging biomarkers, which may be used to non-invasively predict these subtypes based on a radiophenotype. Molecular genetic subtypes SHH p53wt, WNT and non-WNT/non-SHH (Group 4) were significantly distinct in their relation to the 4th ventricle and lower rhombic limb, and extent of edema. Further imaging biomarkers could be identified that differentiate histological subtypes and nuclear-ß-catenin expression patterns. Imaging biomarkers were not congruent to markers identified in pediatric patients implying possible age-related differences.
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