Abstract #4232

RAFF, T1ρ and T2ρ mapping of human gliomas: association with IDH mutation, 1p19q co-deletion and Ki67

Harri Merisaari^1,2,3, Ivan Jambor^3,4, Marko Pesola^3,4, Maria Gardberg⁵, Janek Frantzén⁶, Pekka Jokinen⁶, Hannu Aronen^3,4, Timo Liimatainen^7,8, Heikki Minn⁹, and Aida Kiviniemi^3,4

¹Turku PET Centre, University of Turku, Turku, Finland, ²Department of Information Technology, University of Turku, Turku, Finland, ³Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland, ⁴Department of Diagnostic Radiology, University of Turku, Turku, Finland, ⁵Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland, ⁶Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland, ⁷Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ⁸Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁹Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

Our aim was to study the feasibility of quantitative RAFF, T1ρ_cw, T1ρ_adiab and T2ρ_adiab imaging for the first time in human gliomas and to assess their ability to differentiate gliomas with specific genetic profile. FLAIR lesion segmentation and histogram analysis from parametric maps were applied. Both IDH mutated and 1p19q codeleted gliomas demonstrated a tendency for lower relaxation values compared to IDH wild-type and 1p19q intact gliomas, respectively. Additionally, T2ρ, adiab significantly correlated to Ki-67 and tumor aggressiveness. We conclude that RAFF, T1ρ_cw, T1ρ_adiab and T2ρ_adiab imaging of gliomas is feasible and carry a potential for improving non-invasive glioma characterization.

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