Abstract #4230

Measuring Alanine in Schizophrenia using 2D Correlation Spectroscopy

Adrienne Lee¹, Luke Wang^1,2, Benjamin Rowland¹, Vicky Liao¹, Elisabetta Del Re³, Robert McCarley³, and Alexander Lin¹

¹Center for Clinical Spectroscopy, Brigham and Women’s Hospital, Boston, MA, United States, ²Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA, ³Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Boston, MA

Degree of schizophrenia (SZ) was determined by phase-locking factor (PLF) acquired through an electroencephalogram (EEG). Correlation spectroscopy (COSY) spectra of the chronic SZ patients and age-matched healthy controls were then compared. A significant difference (p < 0.05) between SZ and controls was found in the concentrations of alanine supported by a strong correlation between PLF and alanine levels. These results suggest further studies to examine alanine as a potential biomarker for schizophrenia.

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