Abstract #4221

Disruptions in T1-weighted MRI signal trajectories over age in Bipolar Disorder Type-1

Christopher Dennis Rowley¹, Manpreet Sehmbi¹, Luciano Minuzzi², Benicio Frey², and Nicholas Bock³

¹Neuroscience, McMaster University, Hamilton, ON, Canada, ²Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada, ³Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada

T₁-weighted signal is known to be correlated with age and myelin content. T₁-weighted images with optimized intracortical contrast were taken in subjects aged 17-45. The half cortical depth signal was mapped in 67 healthy controls and 43 individuals diagnosed with bipolar disorder type-1. We investigated the trajectory of the signal with age in each group and it was found that healthy signal trajectory follows a quadratic form with age, while no correlation with age was found in bipolar disorder. We have shown that it is possible to map signal trajectory changes in clinical populations across the cortex.

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