The current study, for the first time, integrated voxel-wise univariate analysis and multivariate pattern classification approach to evaluate the alterations of localized neural connectivity in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD). Our findings (i) suggested the disequilibrium between the fronto-parietal circuit and the cerebellum might be associated with the pathophysiology of OCD, (ii) indicated the translational role of the localized neural connectivity as a potential discriminative pattern to identify OCD at the individual level and (iii) highlighted the hyperactivation of the prefrontal cortex in the pathophysiologic process of OCD.
This abstract and the presentation materials are available to members only; a login is required.