Abstract #4213

Connectome-wide exploration of altered resting-state connectivity in combat veterans with and without PTSD and real-time fMRI neurofeedback training effect on abnormal connectivity

Masaya Misaki¹, Raquel Phillips¹, Vadim Zotev¹, Chung Ki Wong¹, Frank Krueger², Matthew Feldner³, and Jerzy Bodurka^1,4

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Department of Psychology, George Mason University, Fairfax, VA, United States, ³Deptartment of Psychological Science, University of Arkansas, Fayetteville, AR, United States, ⁴College of Engineering, Stephenson School of Biomedical Engineering, University of Oklahoma, Tulsa, OK, United States

In combat veterans with and without PTSD diagnosis, we performed connectome-wide exploration of the whole-brain voxel-by-voxel fMRI connectivity using multivariate distance-based matrix regression (MDMR) analysis to determine connectivity abnormalities without a priori hypothesis. PTSD veterans showed increased connectivity across sensory motor areas and the superior temporal to default mode network (DMN) areas compared to non-trauma-exposed control. Veterans without PTSD also showed altered connectivity in the bilateral insula compared to control. This abnormal connectivity pattern was normalized after real-time fMRI neurofeedback training focused on learning to control left amygdala activity with positive autobiographical memory recall.

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