Abstract #4208

Individual metabolic differences in murine nucleus accumbens (NAc) measured by 1H-MRS at 14.1 Tesla is associated with trait-anxiety levels

Antoine Cherix¹, Thomas Larrieu², Arantxa Duque Moreno³, Hongxia Lei⁴, Santiago Moléon³, Carmen Sandi², and Rolf Gruetter^1,5,6

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Laboratory of Behavioral Genetics (LGC), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Department of Psychobiology, University of Valencia, Valencia, Spain, ⁴Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva, Geneva, Switzerland, ⁶Department of Radiology, University of Lausanne, Lausanne, Switzerland

¹H-MRS was used to study metabolic changes associated with basal anxiety levels in nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) of naive mice. Results indicate some neuroenergetic differences specific to the NAc, which supports the idea that this structure plays a critical role in the etiology of anxiety.

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