Abstract #4164

The association of MRI-detected brain volume change with prenatal exposure to Perfluoroalkyl Substances in teenage

Chao-Yu Shen^1,2,3, Shu-Li Wang⁴, Jeng-Dau Tasi⁵, Ju-Chien Wu², and Jun-Cheng Weng^2,3

¹Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ²Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ³Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁴National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan, ⁵School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan

The current study was to explore the relationship between prenatal exposure to PFASs, determined in maternal blood collected during the third trimester of pregnancy and the children’s brain volume difference at the age of 13-15 years old. The results showed a signiﬁcant negative correlation between the maternal blood PFASs concentrations and the children's brain MRI in multiple different brain areas, including both gray matter and white matter.

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