Milder forms of HIV-associated neurocognitive disorders (HAND) are frequently observed in approximately half of the HIV-infected individuals, even with treatment for HIV infection. Cognitive deficits observed in them can be associated with injury to the frontal and temporal lobes of their brains. The goal of this study was to assess the impact of HIV infection on vulnerable structural connections in these lobar regions in adults perinatally-infected with HIV. Our results indicate that altered connectivity in frontal lobe regions with differentiated modularity and significant alterations in hub patterns at the temporo-parietal junction occurred in the HIV group.
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