Abstract #4155

Reorganization of Brain Connectivity in the Speech and Language Network in the Non-fluent variant of PPA

Maria Luisa Mandelli¹, Christa Watson¹, Eduard Vilaplana², Jesse A Brown¹, Zachary A Miller¹, Isabel H Honey¹, Ariane Welch¹, Miguel A Santos-Santos³, Howard J Rosen¹, Bruce L Miller¹, William W Seeley¹, and Maria Luisa Gorno-Tempini¹

¹Memory and Aging Center, Neurology, University of California, San Francisco, San Francisco, CA, United States, ²Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau – Universitat Autonoma de Barcelona, Spain, ³Fundació ACE, Alzheimer Research Center, Institut Català de Neurociències Aplicades, Barcelona, Spain Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute, Barcelona, Spain

Graph theory analysis is a method recently introduced to study the brain as a network. In this study we investigate the topological distribution of the speech and language functional network in nfvPPA patients characterized by isolated and progressive language impairments. We identified the hubs of the speech and language network in healthy controls and nfvPPA. In patients, the network presented an abnormal topological distribution where right-sided brain regions were recruited. These findings suggest that in nfvPPA this network reorganizes in the presence of localized gray matter volume loss.

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