Abstract #4153

An animal model of comorbid cerebral hypoperfusion and metabolic syndrome

Jessica Livingston-Thomas¹, Greg O. Cron^2,3,4, Therese Gagnon⁵, Anthony Carter⁶, Matthew Jeffers⁵, and Dale Corbett^5,6

¹Cellular and Molecular Medicine, The University of Ottawa, Ottawa, ON, Canada, ²Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, ³The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Radiology, The University of Ottawa, Ottawa, ON, Canada, ⁵Cellular and Molecular Medicine, The University of Ottawa, ⁶Canadian Partnership for Stroke Recovery

Vascular cognitive impairment (VCI) arises from chronic cerebral hypoperfusion and is characterized by executive dysfunction, memory problems, and motor impairments. In countries where people eat highly processed, energy-dense food, there are high rates of VCI. Poor diet is also linked to metabolic syndrome, which is also associated with cognitive dysfunction. Metabolic syndrome and VCI commonly coexist within cardiovascular patients. Due to the translational failure of many promising preclinical treatments for cardiovascular disease, researchers are trying to incorporate human comorbidities within animal disease models. Here, we develop a rat model which combines cerebral hypoperfusion with an unhealthy diet.

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