Abstract #4149

Quantitative Magnetization Transfer Imaging of the Substantia Nigra in Parkinson’s Disease

Paula Trujillo^1,2, Paul E. Summers², Alex K. Smith³, Seth A. Smith^4,5, Antonella Costa², and Daniel O. Claassen¹

¹Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ²Neuroradiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy, ³FMRIB, University of Oxford, Oxford, United Kingdom, ⁴Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁵Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Parkinson’s disease (PD) is characterized by the loss of pigmented dopaminergic neurons in the substantia nigra pars compacta (SNc). The aim of the study was to evaluate the feasibility of rapid magnetization pool size ratio (PSR) mapping as a subset of the magnetization transfer (MT) properties of the SNc in healthy subjects and patients with PD. These results demonstrated the feasibility of performing quantitative PSR mapping in human SN within reasonable scan times, and that PSR is likely the quantitative MT parameter most relevant for PD.

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