Oxidative stress has been implicated as an important pathological mechanism in the development of Alzheimer’s disease (AD). The purpose of this study was to assess whether J-edited 1H MRS levels of glutathione (GSH) – the primary antioxidant in living tissue – are associated with brain amyloidosis, as assessed with PET, and memory in a community-dwelling cohort of nondemented older adults. The results showed an inverse association relating GSH, a sensitive marker of oxidative stress, and amyloidosis, one of the pathological hallmarks of AD, and a weaker association with memory, thereby collectively further implicating oxidative stress in AD pathophysiology.
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