Abstract #4108

Characterizing brain microstructural changes in childhood arterial ischemic stroke using multi-shell diffusion magnetic resonance imaging

Joseph Yuan-Mou Yang^1,2,3, Richard Beare^3,4, Belinda Stojanovski^2,5, Wirginia J Maixner^1,2, Marc L Seal^3,6, and Mark T Mackay^2,5

¹Neurosurgery, Royal Children's Hospital, Melbourne, Australia, ²Neuroscience Research, Murdoch Childrens Research Institution, Melbourne, Australia, ³Developmental Imaging, Murdoch Childrens Research Institution, Melbourne, Australia, ⁴Stroke and aging research group, Department of Medicine, Monash University, Melbourne, Australia, ⁵Neurology, Royal Children's Hospital, Melbourne, Australia, ⁶Paediatrics, University of Melbourne, Melbourne, Australia

Imaging markers that can infer microstructural changes occurring in childhood arterial ischemic stroke (CAIS) may lead to a better understanding of the disease’s neurobiological substrates. We applied both the Neurite Orientation Dispersion and Density Imaging (NODDI) and the Spherical Mean Technique (SMT) diffusion compartment models to two-shell diffusion data acquired in four acute CAIS patients. We demonstrate that parameter estimates derived from the stroke-affected regions were consistent with known microstructural changes described in acute stroke histopathology. The magnitudes of parameter changes were associated with stroke severity, and the motor outcomes at follow-up.

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