Abstract #4101

Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates

Xianjun Li^1,2, Jie Gao¹, Miaomiao Wang¹, Edward S. Hui³, Xiaocheng Wei⁴, and Jian Yang¹

¹Department of Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China, ²Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China, ³Department of Diagnostic Radiology, the University of Hong Kong, Hong Kong, People's Republic of China, ⁴MR Research China, GE Healthcare, Bei Jing, People's Republic of China

Punctate white matter lesions (PWML) are common in preterm neonates. Neurodevelopmental outcome of the neonates is related to the lesion extensions. This study aimed to characterize the extent of microstructural variations for different PWML grades. White matter microstructural variations were different across PWML grades. The severe PWML were associated with extensive microstructural changes. Pattern of increased AD, increased RD, and reduced/unchanged FA was found proximal to the PWML. Unchanged AD, increased RD, and reduced/unchanged FA were observed in the vast regions distal from the PWML. These findings may help in determining outcomes of PWML and treatment strategies.

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