Quantitative Susceptibility Mapping (QSM) has been well used in evaluating the iron quantity changes in adult patients with multiple sclerosis (MS). However, it has not been tested in pediatric MS patients. In the present study, QSM was applied to assess difference of iron quantity in clinically isolated syndrome (CIS) and MS in children. It is shown that QSM provides a superior sensitivity method in the detection iron of changes of MS-related tissue in children, which suggests that QSM may serve as a potential sensitive biomarker in pediatric MS.
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