Hyperoxia gas mixture breathing causes additional oxygen to be dissolved in blood plasma thereby shortening the T1 of arterial blood (T1a). Here, we propose a method estimate T1a during hyperoxia gas breathing by solving a perfusion quantification model for T1a given CBF measured during hyperoxia via phase contrast (PC) of the feeding arteries in the neck. The ratio between PC-based total CBF and ASL-based regional CBF was first determined at baseline, and then applied to normalize the expected ASL-based CBF during hyperoxia. T1a was estimated as 1.46±0.09 s during hyperoxia gas mixture breathing, in reasonable agreement with previous reports.
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