Abstract #3763

Characterization of the power dependency regimes of inhomogeneous Magnetization Transfer (ihMT)

Samira Mchinda¹, Gopal Varma², Valentin H Prevost¹, Arnaud Le Troter¹, Maxime Guye^1,3, Jean Pelletier^1,4, Jean-Philippe Ranjeva¹, David C Alsop², Guillaume Duhamel¹, and Olivier M Girard¹

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ³Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle d'Imagerie Médicale, CEMEREM, Marseille, France, ⁴Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

Inhomogeneous magnetization transfer (ihMT) is a new MRI technique that shows promise for myelin imaging. A significant boost of the ihMT signal intensity is achievable when using a concentrated energy deposition scheme. Here we characterized the power dependency of ihMT for various energy deposition schemes (distributed vs. concentrated RF) and we identified distinct regimes with linear, sub-linear and saturated B1 dependency. This has a strong impact on the ihMT response to variable sequence configurations and on the most suitable conditions for different field strengths, e.g. to enhance sensitivity or provide immunity to B1⁺ inhomogeneities.

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