Abstract #3761

Assessment of Lipid Order in Model Myelin Membrane Systems with MT and ihMT

Scott D. Swanson¹, Mario L. Fabiilli¹, Dasha I. Malyarenko¹, Ashok Srinivasan¹, Zhongliang Zu², and Daniel F. Gochberg²

¹Radiology, University of Michigan, Ann Arbor, MI, United States, ²Radiology, Vanderbilt University, Nashville, TN

We report here a study of MT and enhanced MT (eMT), using dual-sided RF saturation, in model membrane system to measure lipid dynamics and structure in systems of known lipid order. The eMT signal generated by dual-sided RF saturation of phospholipid vesicles is well described by Gaussian line shape and T_2b is easily determined. T_2b of the lipids is related to the lipid order with T_2b(liquid disorder) > T_2b(liquid order) > T_2b(solid order). These tools provide a method to estimate lipid order in vivo.

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