Cognitive impairment (CI) is a significant symptom of multiple sclerosis (MS), is the strongest predictor of unemployment in MS patients, and is critical to the decline of quality of life. There is an unmet need for imaging techniques that probe the pathological substrate of CI at a clinically relevant field strength. To address this need, we have investigated the translation of glutamate-sensitive chemical exchange saturation transfer (GluCEST) MRI to 3T, as glutamate abnormalities have been linked to CI in MS. Our results demonstrate the clinical feasibility of GluCEST imaging for application to studying cortical gray matter glutamate signals in vivo.
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