Abstract #3700

Repeatability of quantitative hyperpolarized 13C MRSI measures of renal metabolism: impact of flow-sensitive gradients

Erin B Adamson¹, Kai D Ludwig¹, Benjamin L Cox^1,2,3, and Sean B Fain^1,4,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Morgridge Institute for Research, Madison, WI, United States, ³Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, United States, ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Real-time quantification of in vivo metabolism with hyperpolarized ¹³C magnetic resonance spectroscopic imaging (MRSI) is currently limited by partial volume effects from intense vascular signal. Flow-sensitive, bipolar gradients are an attractive option for suppressing vascular signal due to their minimal influence on static spins. This work looks at the impact of incorporating bipolar gradients on the quantification and repeatability of hyperpolarized ¹³C MRSI metabolic measures of lactate-to-pyruvate area-under-the-curve ratios (AUC_ratio). The results suggest that incorporating bipolar gradients mitigates vascular partial voluming, increasing measured AUC_ratio, while reducing measurement repeatability, indicated by the larger repeatability coefficients.

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