Susceptibility weighted imaging (SWI) has been widely used to image cerebral venous structures and in vivo iron content. However, it has not been used to image arteries, because of the lack of susceptibility contrast between arteries and the surrounding tissue. In this study, the susceptibility of the arterial blood was purposely modified to make it visible with SWI, by using the USPIO (ultra-small superparamagnetic iron oxide) agent Ferumoxytol. The purpose of this study is to determine the relationship between Ferumoxytol concentration and susceptibility using phantom and simulation studies, and compare these findings with those obtained from in vivo data.
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