Abstract #3603

Multiparametric tumor characterization using simultaneous 1H-MRI, [18F]FDG PET and hyperpolarized [1-13C]pyruvate MRSI

Christian Hundshammer^1,2, Miriam Braeuer¹, Müller Christoph^3,4, Adam Espe Hansen⁵, Jorge Cabello¹, Mathias Schillmaier⁶, Benedikt Feuerecker¹, Stephan Duewel^1,2,7, Schachoff Sylvia¹, Birgit Blechert¹, Michael Michalik¹, Jan-Bernd Hövener^3,4, Steffen J. Glaser², Axel Haase⁷, Franz Schilling¹, Andreas Kjaer⁵, Stephan Nekolla¹, and Schwaiger Markus¹

¹Department of Nuclear Medicine, Klinkum rechts der Isar, Munich, Germany, ²Department of Chemistry, Technical University Munich, Munich, Germany, ³Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁴German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, ⁵Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark, ⁶Department of Radiology, Klinikum rechts der Isar, Munich, Germany, ⁷Deparment of Medical Engineering, Technical University Munich, Munich, Germany

In order to understand complex mechanisms of the tumor biology, multimodal imaging approaches are useful. Here we present a workflow to characterize subcutaneous MAT-B-III tumors in rats on a clinical 3T PET/MR. Proton imaging was used for tumor localization and to characterize tumor cellularity by diffusion-weighted imaging. Glucose uptake and downstream glucose metabolism of pyruvate by lactate dehydrogenase (LDH) was addressed by [¹⁸F]FDG-PET and hyperpolarized [¹³C]pyruvate metabolic imaging. The [¹⁸F]FDG standard uptake values and the LDH activity were consistently and reproducibly higher compared to normal tissue.

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