In this work we propose a novel pulse sequence for measuring chemical exchange rates through a progressive saturation recovery process PRO-QUEST (PROgressive saturation for Quantifying Exchange using Saturation Times). The water magnetization is sampled under non-steady state conditions and saturation is interleaved with the acquisition of images obtained in a single scan. Unlike previous approaches, it provides maps of T1 and B1 , needed for exchange-rate calculations, from the same dataset. The proposed pulse sequence has been successfully applied to obtain exchange rate maps in phantoms and healthy rat brains.
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