Abstract #3577

Prospective longitudinal evaluation of patients with low-grade cartilage injury using gagCEST at 7T

Markus Schreiner^1,2, Vladimir Mlynarik^1,3, Didier Laurent⁴, Vladimir Juras¹, Pavol Szomolanyi¹, Stefan Zbyn^1,5, Celeste Scotti⁴, Joerg Goldhahn⁴, Harry Haber⁴, Ewa Kubiak⁴, Ronenn Roubenoff⁴, Stefan Marlovits⁶, Reinhard Windhager², and Siegfried Trattnig^1,3

¹High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ³Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ⁴Novartis Institutes for Biomedical Research, Basel, Switzerland, ⁵Research Unit of Medical Imaging, Physics and Technology, University of Oulu and Oulu University Hospital, Oulu, Finland, ⁶Depatment of Traumatology, Medical University of Vienna, Vienna, Austria

To the best of our knowledge, this is the first study that employs gagCEST for the longitudinal evaluation of untreated articular cartilage defects. We demonstrate that gagCEST at 7T has the potential of discriminating between cartilage defects, weight bearing and non-weight bearing femoral cartilage and therefore might serve as a biomarker for the evaluation of novel cartilage therapies. Furthermore, our study implies that proper fixation of the examined knee may help to increase the reliability of gagCEST experiments.

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