We show the use of a sugar alcohol sweetener, maltitol, in cancer MRI studies by exploiting its chemical exchange saturation transfer (malCEST) property. The tumor specific accumulation of maltitol in a rat glioma model provides localized, temporal changes in the CEST contrast, which corroborated the gadolinium-enhanced MRI. These findings illustrate the potential application of maltitol in the diagnosis and monitoring of the therapeutic response of cancers, including gliomas in preclinical studies.
This abstract and the presentation materials are available to members only; a login is required.