Phosphorus (31P) metabolites have potential value as markers in liver disease. The increase in field strength from 3 to 7T allows more accurate quantitation of the liver 31P-MRS spectrum. Ten volunteers and eleven patients with liver cirrhosis were scanned using a 16-channel array and a 3D UTE-CSI sequence. Metabolite concentrations were calculated using an endogenous 2.5mM ATP reference. Significant reductions in inorganic phosphate and phosphoenolpyruvate/phosphatidylcholine concentrations were seen, as well as an increase in glycerophosphoethanolamine (P<0.05). The splitting of PDE into its constituent peaks allows more insight into changes in metabolism.
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